Geriatric Medicine

 Research projects

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Research Project

Here you will find details of research projects currently taking place at the department of Geriatric Medicine.  The include the following: 

Longitudinal Cognitive Impairment and Dementia Study DELCODE

The German Center for Neurodegenerative Diseases (DZNE) wants to find out, whether and which subjective cognitive changes may signal a neurodegenerative disease, whether progression of initial cognitive changes predicts the speed of further disease progression, and which determinants of cognitive decline can be identified in the prodromal disease stages.

Alzheimer Disease has a preclinical duration of years, if not decades, until progressive neuronal changes give rise to functional (cognitive) changes, which can initially be compensated and may be experienced only by the affected subject, before objective neuropsychological measures allow one to detect a cognitive decline. We examine new procedures to assess e.g. associative encoding in short-and long-term memory, in order to uncover and track functional deficits in brain regions affected very early in the disease. We are particularly interested how these deficits are associated with biomarkers of the disease (e.g. CSF markers, regional brain volumes), with subjective cognitive disturbances, and with functional impairment in everyday life.

In order to address these questions  we realise comprehensive new observational studies with subjects in putatively prodromal or at-risk states. The identification of subjects in a prodromal or even preclinical disease stage is important because new treatments may probably only have an effect in these early stages, and refined neuropsychological methods can contribute to this risk-assessment.

We are looking for people over the age of 60 with the following profiles: Control subjects, Subjective memory complaints, Mild Cognitive Impairment, Mild Alzheimer's Disease, first degree relatives of patients with Alzheimer's disease.

 Contact: Felix Menne 
Felix.Menne@charite.de

Respectful caring for the agitated elderly (RECAGE)

Project funding:European Commission Horizon 2020
Grant number: 779237

Project duration: 1.1.2018 - 31.12.2022

The treatment of Behavioural and Psychological Symptoms of Dementia (BPSD) continue to raise difficult problems. Both the pharmacologic and non-pharmacologic therapies often fail to achieve the expected results. The aim of this study is to assess the short- and long-term efficacy of a quite novel intervention, the Special Care Unit for patients with BPSD (SCU-B) as well as its cost-effectiveness.

Contact:

M.Sc. Herlind Megges
Herlind.Megges@charite.de

Frontotemporal Lobar Degeneration Disorders Registry (FTD-DESCRIBE)

The aim of the clinical trial "DESCRIBE-FTD" is to observe the development of the different variations of frontotemporal dementia (FTD). Various analyses of the assessed clinical data, neuro-imaging as well as results of biomaterial including genetic analyses are intended.

Data of the trial will be assessed in yearly intervals. To perform scientific analyses blood samples and if applicable cerebrospinal fluid will be obtained, furthermore a head MRI will be conducted.

All subjects with a diagnose of one of the variations of frontotemporal dementia can participate.

Contact: Felix Menne
Felix.Menne@charite.de

Research database

For more details please use the Charité research database.

Clinical Studies

Get information about running clinical studies here.

Selected Publications

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