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Our research team is working on the development of pharmacopsychotherapies that purposefully combine pharmacological and nonpharmacological interventions.This therapeutic model integrates pharmacological agents that are taken only once or a few times in order to augment or catalyze a psychotherapeutic process.

A widely discussed substance is the “attachment hormone” oxytocin. Another substance, D-cycloserine, known from tuberculosis therapy, is being studied as an augmentation strategy of exposure therapy, whereas propranolol, a beta blocker, is thought to be a potential treatment for posttraumatic stress disorder (PTSD) and anxiety disorders due to its memory-modifying effects.

One special section within the broad field of potential pharmacopsychotherapies are the so-called “psychedelic” pharmacopsychotherapies that have been sufficiently developed to reach the threshold of multicenter clinical trials.

One of the psychedelic substances that is being tested is psilocybin, a controlled drug and one of the ingredients of ‘magic mushrooms’. Recent research has suggested that psilocybin may help in treating depression.

Preliminary studies have also shown that another scheduled substance, MDMA (3,4-methylenedioxymethamphetamine) in conjunction with psychotherapy can help people overcome posttraumatic stress disorder (PTSD).

Our group is participating in ongoing, international, multicenter clinical trials with psilocybin and MDMA in more than 20 sites across Europe and North America. We investigate the safety, efficacy and mechanism of action of psilocybin and MDMA delivered in a medically controlled and supportive environment for the treatment of mental health disorders. We do not encourage or condone the recreational use of psychedelics.

A more detailed description of the current trials can be found below.

If you experience sustained psychological distress or symptoms after recreational use of psychedelics, you can seek help in our outpatient clinic.

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression (P-TRD)

This is a randomised controlled phase IIb study of psilocybin therapy in patients with treatment-resistant depression in 21 sites across Europe and North America.

The aim of this trial is to determine whether psilocybin delivered with psychological support and medical supervision is a safe and effective treatment for people with difficult to treat depression. To determine this, the trial collects detailed data on adverse events as well as comparing participant’s ratings of their depression symptoms before and after treatment. The trial is being funded by a life sciences company, COMPASS Pathways Ltd. that received US Food and Drug Administration (FDA) “Breakthrough Therapy” designation in 2018 for their program of psilocybin therapy in treatment-resistant depression.

The trial in our site is approved by the German Federal Institute for Drugs and Medical Devices (BfArM) and the Ethics Committee of LAGeSo (Landesamt für Gesundheit und Soziales Berlin)

For more information on this trial you can refer to

or contact us at psilocybin(at)

Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD

This open-label, lead-in Phase II study is intended to gather data on the safety and effectiveness of manualized MDMA-assisted psychotherapy as a treatment for PTSD. This is the first multi-site study of MDMA-assisted psychotherapy for PTSD in Europe and explores the reproducibility of findings from FDA-regulated trials. The trial is being funded by the non-profit organization MAPS that received FDA “Breakthrough Therapy” designation in 2017 for the program of MDMA-assisted psychotherapy for PTSD.

For more information about MAPS and the MDMA-assisted psychotherapy research program, you can visit their internet sites:

The trial in our site is approved by the German Federal Institute for Drugs and Medical Devices (BfArM. Approval bei the Ethics Committee of LAGeSo (Landesamt für Gesundheit und Soziales Berlin) is still pending.

For more information on this trial, you can contact us at mdma(at)