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Neuropsychological markers of psychiatric disorders
Across, psychiatric disorders, neuropsychological deficits are among the most frequent deficits. These deficits are usually detectable at the beginning of a psychiatric disorder. Based on these premises, all psychiatric patients are carefully characterized regarding their neuropsychological profile to evaluate the differential patterns and courses of neuropsychological deficits in large samples.
If you have questions regarding this project, please contact <//span>franziska.jakob(at)charite.de or michael.dettling(at)charite.de

Mechanisms of clozapine-induced agranulocytosis
This study aims at identification of genetic variations that may lead to life-threatening decrease of white blood cells under therapy with clozapine. Agranulocytosis is a rare, but dangerous condition that restricts the use of clozapine that otherwise is of great importance for therapy of schizophrenia. Early detection of patients at risk fort his adverse event would therefore considerably increase the clinical usability of clozapine. Since 2009, we take part in a world-wide cooperation (Clozapine Induced Agranulocytosis Consortium, CIAC) with centers in the USA (Stanford, Boston, New York) and Europe (London, Stockholm, Kopenhagen) under supervision of the NIMH.<//span>
If you have questions regarding this project, please contact <//span>michael.dettling(at)charite.de

Neurobiology of psychiatric disorders in the post partum<//span>
Psychiatric disorders in the post partum are underrepresented regarding both suitable clinical therapy setting and research. This is remarkable given the opportunity to study specific hypotheses on the etiology of psychiatric disorders, e.g. neuroendocrine pathways or interactions of genetics and environment.<//span>
If you have questions regarding this project, please contact <//span>michael.dettling(at)charite.de

Associations between laterality, nicotine, and schizophrenia<//span>
Here we investigate the associations between cerebral lateralization and nicotine dependence in schizophrenia. Cerebral lateralization is viewed as the specialization of one hemisphere for a specific function, e.g. left-hemispheric dominance for language. Many investigations indicate a disturbed lateralization in schizophrenia. We investigate the tripartite relation between lateralization, nicotine, and schizophrenia as well as their potential interrelations, given that nicotine consumption is considerably higher in schizophrenia than in the normal population and that nicotine may exert an influence on lateralization. This study is conducted in cooperation with the cluster of excellence of the Department of Biopsychology of the Ruhr University Bochum (Prof. O. Güntürkün).<//span>
If you have questions regarding this project, please contact <//span>eric.hahn@charite.de